Distributed enterprise modelling guided by business rules

Enterprise architectures create a technical platform to meet current and future business needs. In this sense, architectural components ensure IT capabilities are modelled in every business process. Current approaches to enterprise architecting tend to focus on reducing the effort required to design business processes by using the resources provided by the Web to support new inter-organisational processes. This often leads to the development of services where some generic features or rules are particularly similar across different processes. We describe and illustrate the use of business rules to share components across many different views. Having a business rule front end lets a component offer different access rights and visibility to different clients. We present an approach that might be used in the process of enterprise architecting in conjunction with a service-oriented perspective.Eje: Ingeniería de softwareRed de Universidades con Carreras en Informática (RedUNCI

Distributed enterprise modelling guided by business rules

Enterprise architectures create a technical platform to meet current and future business needs. In this sense, architectural components ensure IT capabilities are modelled in every business process. Current approaches to enterprise architecting tend to focus on reducing the effort required to design business processes by using the resources provided by the Web to support new inter-organisational processes. This often leads to the development of services where some generic features or rules are particularly similar across different processes. We describe and illustrate the use of business rules to share components across many different views. Having a business rule front end lets a component offer different access rights and visibility to different clients. We present an approach that might be used in the process of enterprise architecting in conjunction with a service-oriented perspective.Eje: Ingeniería de softwareRed de Universidades con Carreras en Informática (RedUNCI

Del triángulo al nodo : La experiencia de vinculación entre la FAMAF (UNC) y el Córdoba Technology Cluster para el desarrollo de inteligencia artificial

En marzo de 2018 la Facultad de Matemática, Astronomía, Física y Computación (FAMAF) de la Universidad Nacional de Córdoba (UNC) y el Córdoba Technology Cluster (CTC) firmaron un convenio para conformar un nodo orientado a: El desarrollo de capacidades, productos y servicios vinculados a la inteligencia artificial (IA), la capacitación en temáticas referentes a la IA para formar recursos humanos (RR.HH) y la realización de esfuerzos conjuntos para crear una o varias supercomputadoras que provean el poder de computo necesario para desarrollar los productos que surjan de la interacción en el Nodo. De esta iniciativa también es parte el Centro de Computación de Alto Desempeño (CCAD) de la UNC. El mencionado convenio fue el punto culminante de una colaboración previa entre la FAMAF y el CTC, constituyéndose, a su vez, en el hito iniciador de una nueva etapa mucho más institucionalizada y con objetivos más ambiciosos. El Nodo surgido del acuerdo FAMAF-CTC ha sido una puesta en práctica de la concepción colaborativa expuesta a fines de la década de 1960 por Jorge Sábato en su célebre idea del Triángulo que lleva su apellido (Sábato – Botana, 1968). En este esquema conceptuarl el desarrollo requiere una dinámica cooperación entre el Estado, la academia y el sector productivo.Sociedad Argentina de Informática e Investigación Operativ

Del triángulo al nodo : La experiencia de vinculación entre la FAMAF (UNC) y el Córdoba Technology Cluster para el desarrollo de inteligencia artificial

En marzo de 2018 la Facultad de Matemática, Astronomía, Física y Computación (FAMAF) de la Universidad Nacional de Córdoba (UNC) y el Córdoba Technology Cluster (CTC) firmaron un convenio para conformar un nodo orientado a: El desarrollo de capacidades, productos y servicios vinculados a la inteligencia artificial (IA), la capacitación en temáticas referentes a la IA para formar recursos humanos (RR.HH) y la realización de esfuerzos conjuntos para crear una o varias supercomputadoras que provean el poder de computo necesario para desarrollar los productos que surjan de la interacción en el Nodo. De esta iniciativa también es parte el Centro de Computación de Alto Desempeño (CCAD) de la UNC. El mencionado convenio fue el punto culminante de una colaboración previa entre la FAMAF y el CTC, constituyéndose, a su vez, en el hito iniciador de una nueva etapa mucho más institucionalizada y con objetivos más ambiciosos. El Nodo surgido del acuerdo FAMAF-CTC ha sido una puesta en práctica de la concepción colaborativa expuesta a fines de la década de 1960 por Jorge Sábato en su célebre idea del Triángulo que lleva su apellido (Sábato – Botana, 1968). En este esquema conceptuarl el desarrollo requiere una dinámica cooperación entre el Estado, la academia y el sector productivo.Sociedad Argentina de Informática e Investigación Operativ

Del triángulo al nodo : La experiencia de vinculación entre la FAMAF (UNC) y el Córdoba Technology Cluster para el desarrollo de inteligencia artificial

En marzo de 2018 la Facultad de Matemática, Astronomía, Física y Computación (FAMAF) de la Universidad Nacional de Córdoba (UNC) y el Córdoba Technology Cluster (CTC) firmaron un convenio para conformar un nodo orientado a: El desarrollo de capacidades, productos y servicios vinculados a la inteligencia artificial (IA), la capacitación en temáticas referentes a la IA para formar recursos humanos (RR.HH) y la realización de esfuerzos conjuntos para crear una o varias supercomputadoras que provean el poder de computo necesario para desarrollar los productos que surjan de la interacción en el Nodo. De esta iniciativa también es parte el Centro de Computación de Alto Desempeño (CCAD) de la UNC. El mencionado convenio fue el punto culminante de una colaboración previa entre la FAMAF y el CTC, constituyéndose, a su vez, en el hito iniciador de una nueva etapa mucho más institucionalizada y con objetivos más ambiciosos. El Nodo surgido del acuerdo FAMAF-CTC ha sido una puesta en práctica de la concepción colaborativa expuesta a fines de la década de 1960 por Jorge Sábato en su célebre idea del Triángulo que lleva su apellido (Sábato – Botana, 1968). En este esquema conceptuarl el desarrollo requiere una dinámica cooperación entre el Estado, la academia y el sector productivo.Sociedad Argentina de Informática e Investigación Operativ

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

The giardial ENTH protein participates in lysosomal protein trafficking and endocytosis

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2015-03-09T18:33:27Z No. of bitstreams: 1 Feliziani C The giardia....pdf: 2028133 bytes, checksum: 2ba0e20be87fcdfa8535761012ee5e0f (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2015-03-09T18:35:02Z (GMT) No. of bitstreams: 1 Feliziani C The giardia....pdf: 2028133 bytes, checksum: 2ba0e20be87fcdfa8535761012ee5e0f (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2015-03-09T18:52:58Z (GMT) No. of bitstreams: 1 Feliziani C The giardia....pdf: 2028133 bytes, checksum: 2ba0e20be87fcdfa8535761012ee5e0f (MD5)Made available in DSpace on 2015-03-09T18:52:58Z (GMT). No. of bitstreams: 1 Feliziani C The giardia....pdf: 2028133 bytes, checksum: 2ba0e20be87fcdfa8535761012ee5e0f (MD5) Previous issue date: 2015Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. INIMEC, CONICET. Córdoba, ArgentinaUniversidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. INIMEC, CONICET. Córdoba, ArgentinaUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario. Rosario, ArgentinaUniversidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. INIMEC, CONICET. Córdoba, ArgentinaFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz.Serviço de Microscopia Eletrônica. Salvador, BA, BrasilUniversidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. INIMEC, CONICET. Córdoba, ArgentinaIn the protozoa parasite Giardia lamblia, endocytosis and lysosomal protein trafficking are vital parasite-specific processes that involve the action of the adaptor complexes AP-1 and AP-2 and clathrin. In this work, we have identified a single gene in Giardia encoding a protein containing an ENTH domain that defines monomeric adaptor proteins of the epsin family. This domain is present in the epsin or epsin-related (epsinR) adaptor proteins, which are implicated in endocytosis and Golgi-to-endosome protein trafficking, respectively, in other eukaryotic cells. We found that GlENTHp (for G. lamblia ENTH protein) localized in the cytosol, strongly interacted with PI3,4,5P3,was associatedwith the alpha subunit of AP-2, clathrin and ubiquitin andwas involved in receptor-mediated endocytosis. It also bonded PI4P, the gamma subunit of AP-1 and was implicated in ER-to- PV trafficking. Alteration of the GlENTHp function severely affected trophozoite growth showing an unusual accumulation of dense material in the lysosome-like peripheral vacuoles (PVs), indicating that GlENTHp might be implicated in themaintenance of PV homeostasis. In this study,we showed evidence suggesting that GlENTHp might function as a monomeric adaptor protein supporting the findings of other group indicating that GlENTHp might be placed at the beginning of the ENTH family

Annual Report 2022

This report summarises the activities and main achievements of the CERN strategic R&D programme on technologies for future experiments during the year 202

Extension of the R&D Programme on Technologies for Future Experiments

we have conceived an extension of the R&D programme covering the period 2024 to 2028, i.e. again a 5-year period, however with 2024 as overlap year. This step was encouraged by the success of the current programme but also by the Europe-wide efforts to launch new Detector R&D collaborations in the framework of the ECFA Detector R&D Roadmap. We propose to continue our R&D programme with the main activities in essentially the same areas. All activities are fully aligned with the ECFA Roadmap and in most cases will be carried out under the umbrella of one of the new DRD collaborations. The program is a mix of natural continuations of the current activities and a couple of very innovative new developments, such as a radiation hard embedded FPGA implemented in an ASIC based on System-on-Chip technology. A special and urgent topic is the fabrication of Al-reinforced super-conducting cables. Such cables are a core ingredient of any new superconducting magnet such as BabyIAXO, PANDA, EIC, ALICE-3 etc. Production volumes are small and demands come in irregular intervals. Industry (world-wide) is no longer able and willing to fabricate such cables. The most effective approach (technically and financially) may be to re-invent the process at CERN, together with interested partners, and offer this service to the community